Understanding The MicroRNA-146a Role in Psoriasis

Abstract

Psoriasis is an inflammatory skin condition that is immune-mediated and has a strong hereditary component where the pathophysiology is largely dependent on the stimulation of Interleukin 17 signaling. The contribution of microRNAs and other non-coding RNAs to the disease's susceptibility has not been well understood. MicroRNAs have a significant role in the pathophysiology of psoriasis, according to new studies. Psoriasis patients' skin and peripheral blood mononuclear cells have repeatedly been shown to overexpress microRNA-146a, a major negative regulator of inflammation. The purpose of this review was to investigate the role of microRNA-146a in illness and to show how it relates to psoriasis. According to the review's results, microRNA-146a that targets tumor necrosis factor receptor-associated factor 6 and IL-1 receptor-associated kinase 1 is a common downstream target adapter protein for both cytokine and Toll-like receptor signaling pathways. Additionally, microRNA-146a decreases the production of pro-inflammatory cytokines by blocking the activity of nuclear factor-kappa B. According to these results, microRNA-146a was a major negative regulator of autoimmunity in psoriasis and serves as a vital physiological brake to stop the overactivation of inflammatory response pathways. More function research, however, will be necessary to pinpoint the specifics of the procedure and may significantly advance our knowledge of the hereditary component of psoriasis.