In Vitro: Effects of tetrahydrolipstatin upon phagocytic function

Abstract

   In recent years, anti-obesity have become increasingly widespread. With this growing use, it has become essential to study the effects of these drugs on vital physiological activities in the body to better understand both their efficacy and potential adverse effects. One of these vital processes is phagocytosis. This study aimed to evaluate the effects of the anti-obesity drug Orlistat on phagocytic activity .The phagocytic function was assessed using a Phagocytic Function Test. Different dilutions and concentrations of Orlistat were applied to phagocytic cells. The cells were incubated and examined at two different time intervals: 30 minutes and 1 hour dilutions.   The results indicated no direct effect and no statistically significant difference in phagocytic activity when different concentrations of Orlistat were applied to the cells and assessed after 30 minutes and 1 hour of incubation. However, a significant difference (p < 0.05) was observed when comparing the results between the first and third. Although Orlistat did not exhibit a significant impact on phagocytic activity within the initial 30 to 60 minutes of exposure, the observed differences between specific slides suggest that extended exposure or experimental variation may influence phagocytic response.